Innovative two-dimensional nanomaterials for photo-thermal therapy of melanoma

Project title: Innovative two-dimensional nanomaterials for photo-thermal therapy of melanoma 
Project contract number: 1232462
Project implementation deadline: 18.05.2023. - 17.05.2025. 
Total project funding: 162 499,20 EUR  
Research manager: (Dr.) Volodymyr Deineka, e-pasts:volodymyr.deineka@lu.lv 
About the project: The “Innovative two-dimensional nanomaterials for photo-thermal therapy (PTT) of melanoma” project scope is developing a new effective anticancer treatment strategy based on the targeted PTT effect using MXene nanosheets. 
Project tasks: Using novel technologies, we are looking to develop a concept of targeting therapy of malignant tumours with minimal side effects. The project will be implemented with the close cooperation of Prof. Maksym Pogorelov - expert in biomaterials (LU), Prof. Una Riekstiņa – expert in pharmacology and cell biology, Prof. Yuriy Gogotsi - Director of A.J. Drexel Nanomaterials Institute, who discovered a novel class of 2D materials – MXenes, and the world leader in the production of MXenes - Carbone Ukraine (CEO- Alex Gogotsi). 
The tasks of the project are to prepare conference theses and 3 scientific publications.

Dr V. Deineka presents first year results of the project at the weekly IAPS Scientific Seminar

At the scientific seminar of the Institute of Atomic Physics and Spectroscopy on January 4, 2024, Dr. Volodymyr Deineka presented the results of the MSCA4Ukraine project "Innovative two-dimensional nanomaterials for photo-thermal therapy of melanoma" achieved in the first 7 months of the project. existing versions of MXenes that can be used in biomedical research were demonstrated. It is presented that 2D titanium carbide nanosheets are best suited for photothermal therapy with an infrared laser with a wavelength of 808 nm as a photosensitizer. The most essential ISO standards for the study of biomaterials are described. It describes what methods and cellular technologies were used to assess the toxicity and biocompatibility of these nanomaterials. Cooperation is presented with laboratories within the University of Latvia and international collaboration (published 05.02.2024.).